Ammonium Hydroxide → 3,5-Dichloro-3-pyridylamine

HRID 456705

반응식

Cl[C:2]1[C:7]([Cl:8])=[CH:6][C:5]([Cl:9])=[CH:4][N:3]=1.[OH-].[NH4+:11]>>[NH2:11][C:2]1[C:7]([Cl:8])=[CH:6][C:5]([Cl:9])=[CH:4][N:3]=1

참가 물질

반응물 2

HCID 14923Ammonium Hydroxide

HCID 27666Pyridine, 2,3,5-trichloro-

생성물 1

HCID 778863,5-Dichloro-3-pyridylamine

실험 절차

2,3,5-Trichloropyridine (20 g, 0.11 moles) was placed in a steel bomb and treated with ammonium hydroxide (300 mL) at 190° C. in similar manner as described in Example 2 to give 2-amino-3,5-dichloropyridine (15 g) as a white solid. 1H NMR (CDCl3) δ 7.92 (d, 1H), 7.48 (d, 1H), 5.1 (broad s, 2H); MS m/z 163 (M+H).

출처 및 근거

ORD 기록: ord-e4551d28495c451cb2bebf3e0561a601
출처 데이터셋: uspto-grants-2007_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07186714B2

연결된 노트

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