Pyridine → Benzyl 4-[5-(diethoxymethyl)-1-methyl-1H-pyrazol-3-yl]phenylcarbamate

HRID 456793노트

반응식

HRID 456793 반응식
[CH2:1]([O:3][CH:4]([O:18][CH2:19][CH3:20])[C:5]1[N:9]([CH3:10])[N:8]=[C:7]([C:11]2[CH:17]=[CH:16][C:14]([NH2:15])=[CH:13][CH:12]=2)[CH:6]=1)[CH3:2].N1C=CC=CC=1.Cl[C:28]([O:30][CH2:31][C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1)=[O:29]>ClCCl>[CH2:19]([O:18][CH:4]([O:3][CH2:1][CH3:2])[C:5]1[N:9]([CH3:10])[N:8]=[C:7]([C:11]2[CH:12]=[CH:13][C:14]([NH:15][C:28](=[O:29])[O:30][CH2:31][C:32]3[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=3)=[CH:16][CH:17]=2)[CH:6]=1)[CH3:20]

참가 물질

5

반응물 3

HCID 1049PyridineHCID 10387Benzyl chloroformateHCID 184385954-[5-(Diethoxymethyl)-1-methyl-1H-pyrazol-3-yl]aniline2회

생성물 1

HCID 18438601Benzyl 4-[5-(diethoxymethyl)-1-methyl-1H-pyrazol-3-yl]phenylcarbamate수율 109%

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

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온도
0 °C

실험 절차

4-[5-(Diethoxymethyl)-1-methyl-1H-pyrazol-3-yl]aniline (Intermediate 10, 5.9 g, 21.5 mmol), and pyridine (4 ml, 50 mmol) were dissolved in dichloromethane (25 ml) at 0° C. Benzyl chloroformate (3.8 ml, 26.7 mmol) was added slowly over 5 minutes and the resulting mixture was stirred at 0° C. for 30 min. The mixture was diluted with dichloromethane and washed with 1M HCl, saturated NaCl, then dried over sodium sulfate and evaporated give the title compound as a thick light orange oil (9.6 g).

후처리

  1. washwashed with 1M HCl, saturated NaCl
  2. dry with materialdried over sodium sulfate
  3. customevaporated

출처 및 근거

ORD 기록
ord-e8c08db061024efb885fb567580e9fd0
출처 데이터셋
uspto-grants-2007_03
특허 번호
US07186738B2

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