Potassium Hydroxide → 4-Methoxy-2-(prop-2-en-1-yloxy)benzoic acid

HRID 456805

반응식

HRID 456805 반응식
[CH2:1]([O:4][C:5]1[CH:14]=[C:13]([O:15][CH3:16])[CH:12]=[CH:11][C:6]=1[C:7]([O:9]C)=[O:8])[CH:2]=[CH2:3].[OH-].[K+]>CO.CCOC(C)=O>[CH2:1]([O:4][C:5]1[CH:14]=[C:13]([O:15][CH3:16])[CH:12]=[CH:11][C:6]=1[C:7]([OH:9])=[O:8])[CH:2]=[CH2:3]

참가 물질

5

반응물 2

HCID 14797Potassium Hydroxide2회HCID 10242646Methyl 2-(allyloxy)-4-methoxybenzoate

생성물 1

HCID 215068784-Methoxy-2-(prop-2-en-1-yloxy)benzoic acid

시약·촉매·용매 2

HCID 887Methanol용매HCID 8857Ethyl Acetate용매

실험 절차

To a solution of 2 (2.5 g, 11 mmol) in aqueous methanol (30 mL) was added KOH (1 eq, 630 mg). Reaction was heated to 50° C. for 12 hours before the addition of more KOH (630 mg). After 12 hours, the mixture was cooled, diluted with EtOAc and washed with 1M HCl. Aqueous layer was extracted with EtOAc (3×). Combined organic layers, dried over Na2SO4, and concentrated. Product was isolated as an off white solid and used without further purification.

후처리

  1. customReaction
  2. temperaturethe mixture was cooled
  3. washwashed with 1M HCl
  4. extractionAqueous layer was extracted with EtOAc (3×)
  5. dry with materialCombined organic layers, dried over Na2SO4
  6. concentrationconcentrated
  7. customProduct was isolated as an off white solid
  8. customused without further purification

출처 및 근거

ORD 기록
ord-7a610adfa43f42618315f674ee0c8a30
출처 데이터셋
uspto-grants-2007_03
특허 번호
US07186746B2

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