methyl 2-{[6-(1-benzyl-5-phenyl-1H-pyrrol-2-yl)-2-naphthyl]oxy}-3-phenylpropanoate → 2-{[6-(1-Benzyl-5-phenyl-1H-pyrrol-2-yl)-2-naphthyl]oxy}-3-phenylpropanoic acid

HRID 456819노트

반응식

HRID 456819 반응식
[CH2:1]([N:8]1[C:12]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[CH:11][CH:10]=[C:9]1[C:19]1[CH:20]=[C:21]2[C:26](=[CH:27][CH:28]=1)[CH:25]=[C:24]([O:29][CH:30]([CH2:35][C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=1)[C:31]([O:33]C)=[O:32])[CH:23]=[CH:22]2)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>O>[CH2:1]([N:8]1[C:12]([C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=2)=[CH:11][CH:10]=[C:9]1[C:19]1[CH:20]=[C:21]2[C:26](=[CH:27][CH:28]=1)[CH:25]=[C:24]([O:29][CH:30]([CH2:35][C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=1)[C:31]([OH:33])=[O:32])[CH:23]=[CH:22]2)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

3

반응물 1

HCID 18439043methyl 2-{[6-(1-benzyl-5-phenyl-1H-pyrrol-2-yl)-2-naphthyl]oxy}-3-phenylpropanoate

생성물 1

HCID 116565842-{[6-(1-Benzyl-5-phenyl-1H-pyrrol-2-yl)-2-naphthyl]oxy}-3-phenylpropanoic acid수율 90%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

In a similar manner as described in step 7 of Example 1, the title compound was prepared from methyl 2-{[6-(1-benzyl-5-phenyl-1H-pyrrol-2-yl)-2-naphthyl]oxy}-3-phenylpropanoate (0.145 g, 0.270 mmol), prepared in the previous step, and the addition of water (3 mL) to the reaction mixture. After the volatiles were removed under reduced pressure, the residue was partitioned between water and methylene chloride. The layers were separated and the aqueous layer was extracted one time with methylene chloride. The combined extracts were dried (MgSO4), filtered and the solvent removed under reduced pressure to give the title compound as an off-white solid (0.127 g, 90%), mp 70–80° C. Elemental Analysis for C36H29NO3.0.48 H2O Calc'd: C, 81.23; H, 5.67; N, 2.63. Found: C, 80.67; H 6.28; N, 2.36.

후처리

  1. customprepared in the previous step
  2. customAfter the volatiles were removed under reduced pressure
  3. customthe residue was partitioned between water and methylene chloride
  4. customThe layers were separated
  5. extractionthe aqueous layer was extracted one time with methylene chloride
  6. dry with materialThe combined extracts were dried (MgSO4)
  7. filtrationfiltered
  8. customthe solvent removed under reduced pressure

출처 및 근거

ORD 기록
ord-fba7a89705f547f58e8ee32c2cf0590b
출처 데이터셋
uspto-grants-2007_03
특허 번호
US07186749B2

반응 노트

불러오는 중…