Formic Acid → Methyl 5-acetyl-2-chlorobenzoate

HRID 456872노트

반응식

HRID 456872 반응식
[CH3:1][O:2][C:3](=[O:17])[C:4]1[CH:9]=[C:8]([C:10]#[C:11][Si](C)(C)C)[CH:7]=[CH:6][C:5]=1[Cl:16].C(O)=[O:19]>>[CH3:1][O:2][C:3](=[O:17])[C:4]1[CH:9]=[C:8]([C:10](=[O:19])[CH3:11])[CH:7]=[CH:6][C:5]=1[Cl:16]

참가 물질

3

반응물 2

HCID 284Formic AcidHCID 57422929Methyl 2-chloro-5-((trimethylsilyl)ethynyl)benzoate

생성물 1

HCID 58818179Methyl 5-acetyl-2-chlorobenzoate

실험 절차

A mixture of 2-chloro-5-trimethylsilanylethynyl-benzoic acid methyl ester (3.2 g, 12 mmol) in formic acid (50 mL) was heated at reflux for 16 h. The mixture was cooled to room temperature and concentrated in vacuo. The residue was diluted with ethyl acetate and washed with saturated aqueous sodium bicarbonate, water and brine. The organic layer was dried, filtered and concentrated in vacuo to afford the title compound (1.4 g).

후처리

  1. temperaturewas heated
  2. temperatureat reflux for 16 h
  3. concentrationconcentrated in vacuo
  4. additionThe residue was diluted with ethyl acetate
  5. washwashed with saturated aqueous sodium bicarbonate, water and brine
  6. customThe organic layer was dried
  7. filtrationfiltered
  8. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-29e3c43a88bd4457aa7eeb1e253f5f2b
출처 데이터셋
uspto-grants-2007_03
특허 번호
US07186742B2

반응 노트

불러오는 중…