Water → 2,5-Difluoro-4-(pyrrol-1-yl)benzoic acid

HRID 4569노트

반응식

HRID 4569 반응식
[F:1][C:2]1[CH:10]=[C:9]([NH2:11])[C:8]([F:12])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].CO[C:15]1(OC)[CH2:19][CH2:18][CH2:17]O1.O>C(O)(=O)C>[F:1][C:2]1[CH:10]=[C:9]([N:11]2[CH:15]=[CH:19][CH:18]=[CH:17]2)[C:8]([F:12])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5]

참가 물질

5

반응물 3

HCID 962WaterHCID 11788317DimethoxytetrahydrofuraneHCID 201514774-Amino-2,5-difluorobenzoic acid

생성물 1

HCID 201514742,5-Difluoro-4-(pyrrol-1-yl)benzoic acid수율 79.2%

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

5.2 grams (0.03 mol) of 2,5-difluoro-4-aminobenzoic acid, melting at 250°-3°, are dissolved in 60 ml of glacial acetic acid, and 4 grams (0.03 mol) of dimethoxytetrahydrofuran are added. The mixture is heated at the boil for 10 minutes, 20 ml of water are added and the resulting mixture is left to cool. The precipitate formed is filtered off and washed with water to give 5.3 grams of a solid melting at 196°-8° C.

후처리

  1. temperatureThe mixture is heated at the boil for 10 minutes
  2. waitthe resulting mixture is left
  3. temperatureto cool
  4. customThe precipitate formed
  5. filtrationis filtered off
  6. washwashed with water

출처 및 근거

ORD 기록
ord-dc223d62d465498286c60c57753211e7
출처 데이터셋
uspto-grants-1988_02
특허 번호
US04727080

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