참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Ethanolamine | HCID 700 | — |
| 반응물 | 3,5-Dibromoimidazo[1,2-a]pyrazine | HCID 14207592 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 용매 | Isopropanol methylene chloride | HCID 21966342 | — |
| 생성물 | 2-[(3-Bromoimidazo[1,2-a]pyrazin-8-yl)amino]ethan-1-ol | HCID 21070904 | 33.5% |
반응 단계
To a solution of 3,5-dibromo-imidazo[1,2-a]pyrazine (D) (400 mg, 1.44 mmol) in dioxane (2 ml) was added ethanolamine (0.436 ml, 7.22 mmol). The mixture was heated at 80° C. in sealed tube for 5 hr. The mixture was then cooled to rt, diluted with 20% IPA/DCM and water. The organic layer was washed with brine, dried and concentrated. The residue was purified on a silica gel column to give 124 mg (yield 33%) of the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07186832B2 |
|---|
| 출처 데이터셋 | uspto-grants-2007_03 |
|---|
| ORD ID | ord-1b41f4ec3b7149db8c633ee44d33df9a |
|---|
| 출처 메모 | uspto-grants-2007_03 |
|---|
