Benzenemethanamine, 2,4-dichloro-N-methyl- → 3-(6,8-Dichloro-2-ethyl-1,2,3,4-tetrahydroisoquinolin-4-yl)benzene-1-sulfonyl chloride

HRID 45711

반응식

HRID 45711 반응식
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[C:10]([Cl:12])[CH:11]=1)[CH2:8][N:7]([CH3:13])[CH2:6][CH:5]2[C:14]1[CH:15]=[C:16]([S:20]([Cl:23])(=[O:22])=[O:21])[CH:17]=[CH:18][CH:19]=1.Cl[C:25]1C=C(Cl)C=CC=1CNC>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[C:10]([Cl:12])[CH:11]=1)[CH2:8][N:7]([CH2:13][CH3:25])[CH2:6][CH:5]2[C:14]1[CH:15]=[C:16]([S:20]([Cl:23])(=[O:22])=[O:21])[CH:17]=[CH:18][CH:19]=1

참가 물질

3

반응물 2

HCID 485424Benzenemethanamine, 2,4-dichloro-N-methyl-HCID 866723303-(6,8-Dichloro-2-methyl-1,2,3,4-tetrahydroisoquinolin-4-yl)benzene-1-sulfonyl chloride

생성물 1

HCID 866723453-(6,8-Dichloro-2-ethyl-1,2,3,4-tetrahydroisoquinolin-4-yl)benzene-1-sulfonyl chloride

실험 절차

Using procedures outlined in Example 1 to prepare intermediate 1.6, substituting N-(2,4-dichlorobenzyl)ethanamine for 1-(2,4-dichlorophenyl)-N-methylmethanamine, the title compound was prepared as a hydrochloride salt.

출처 및 근거

ORD 기록
ord-6b9ffe09322b413fa1a1fabdbc8d32ba
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08541448B2

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