N-Phenylhydroxylamine → 4-(2-oxazolyl)-phenyl-N-phenylnitrone
반응식
[O:1]1[CH:5]=[CH:4][N:3]=[C:2]1[C:6]1[CH:13]=[CH:12][C:9]([CH:10]=O)=[CH:8][CH:7]=1.[C:14]1([NH:20][OH:21])[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>C(O)C>[O:1]1[CH:5]=[CH:4][N:3]=[C:2]1[C:6]1[CH:13]=[CH:12][C:9]([CH:10]=[N+:20]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[O-:21])=[CH:8][CH:7]=1참가 물질
4
반응 조건
- 온도
- 5 °C
실험 절차
A mixture of 4-(2-oxazolyl)-benzaldehyde (1 eq., 6.3 gm) and N-phenyl-hydroxyamine (1 eq., 3.9 gm) was refluxed in ethanol (100 ml) for 30 minutes and concentrated to a volume of 50 ml. An equal amount (50 ml) of water was added and the mixture was cooled in a refrigerator at 5° C. overnight. White crystals were obtained, which were isolated by filtration and dried, producing 6.7 gm of 4-(2-oxazolyl)-phenyl-N-phenylnitrone.