Sodium Methoxide → HCID 69014017, 화합물

HRID 457509노트

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HRID 457509 반응식
[OH:1][CH2:2][CH2:3][CH2:4][C:5]1[CH:10]=[CH:9][C:8]([CH2:11][C:12]2[C:13]([O:21][C@@H:22]3[O:39][C@H:38]([CH2:40][O:41]C(=O)C)[C@@H:33]([O:34]C(=O)C)[C@H:28]([O:29]C(=O)C)[C@H:23]3[O:24]C(=O)C)=[N:14][NH:15][C:16]=2[C:17]([F:20])([F:19])[F:18])=[CH:7][CH:6]=1.C[O-].[Na+]>CO>[C@@H:22]1([O:21][C:13]2[C:12]([CH2:11][C:8]3[CH:7]=[CH:6][C:5]([CH2:4][CH2:3][CH2:2][OH:1])=[CH:10][CH:9]=3)=[C:16]([C:17]([F:20])([F:19])[F:18])[NH:15][N:14]=2)[O:39][C@H:38]([CH2:40][OH:41])[C@@H:33]([OH:34])[C@H:28]([OH:29])[C@H:23]1[OH:24]

참가 물질

4

반응물 2

HCID 10942334Sodium MethoxideHCID 691344624-{[4-(3-hydroxypropyl)phenyl]methyl}-5-trifluoromethyl-3-(2,3,4,6-tetra-O-acetyl-beta-D-glucopyranosyloxy)-1H-pyrazole

생성물 1

HCID 69014017HCID 69014017, 화합물수율 51.5%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of 4-{[4-(3-hydroxypropyl)phenyl]methyl}-5-trifluoromethyl-3-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyloxy)-1H-pyrazole (0.45 g) in methanol (7 mL) was added sodium methoxide (28% methanol solution, 0.068 mL), and the mixture was stirred at room temperature for 30 minutes. The reaction mixture was concentrated under reduced pressure, and the residue was purified by column chromatography on silica gel (eluent: dichloromethane/methanol=6/1) to give 3-(β-D-glucopyranosyloxy)-4-{[4-(3-hydroxypropyl)phenyl]methyl}-5-trifluoromethyl-1H-pyrazole (0.17 g).

후처리

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. customthe residue was purified by column chromatography on silica gel (eluent: dichloromethane/methanol=6/1)

출처 및 근거

ORD 기록
ord-ccc3d49f04de4335ab65f477829f0108
출처 데이터셋
uspto-grants-2007_03
특허 번호
US07189702B2

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