HCID 20760150, 화합물 → HCID 67378457, 화합물

반응식

[OH:1][C@H:2]([CH2:16][OH:17])[CH2:3][O:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[CH2:11][CH2:12][CH2:13][CH2:14][NH2:15].C(NCCCCC1C=CC=CC=1OC[C@@H](O)CO)(OCC1C=CC=CC=1)=O>>[OH:1][C@@H:2]([CH2:16][OH:17])[CH2:3][O:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[CH2:11][CH2:12][CH2:13][CH2:14][NH2:15]

참가 물질

반응물 2

HCID 20760150HCID 20760150, 화합물

HCID 673657434-{[(2R)-2,3-Dihydroxypropyloxy]phenyl}butylamine

생성물 1

HCID 67378457HCID 67378457, 화합물수율 99%

실험 절차

Compound 73 was prepared in a similar fashion to the synthesis of compound 70 starting from compound 72 (1.67 g, 4.5 mmol). Amine 73 (1.06 g, 99%) was isolated as a white solid. 1H NMR (300 MHz, DMSO-d6) δ 1.32 (m, 2H), 1.54 (m, 2H) 2.55 (m, 2H), 3.45 (m, 2H), 3.75 (m, 3H), 3.94 (m, 2H), 6.83 (d, 2H), 7.08 (d, 2H).

출처 및 근거

ORD 기록: ord-174884ba832d461790c76f5063f95ecc
출처 데이터셋: uspto-grants-2007_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07189719B2

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