Spiro(5-nitroindane)-2,5'-hydantoin → 5'-Amino-1',3'-dihydrospiro[imidazolidine-4,2'-indene]-2,5-dione
반응식
[N+:1]([C:4]1[CH:5]=[C:6]2[C:10](=[CH:11][CH:12]=1)[CH2:9][C:8]1([C:16](=[O:17])[NH:15][C:14](=[O:18])[NH:13]1)[CH2:7]2)([O-])=O>CCOC(C)=O.CO.[Pd]>[NH2:1][C:4]1[CH:5]=[C:6]2[C:10](=[CH:11][CH:12]=1)[CH2:9][C:8]1([C:16](=[O:17])[NH:15][C:14](=[O:18])[NH:13]1)[CH2:7]2참가 물질
5
실험 절차
To a suspension of (±)-5′-nitro-spiro[imidazolidine-4,2′-indane]-2,5-dione (1.77 g, 7.16 mmol) in EtOAc (100 mL) and MeOH (100 mL) was added 10% Pd/C (400 mg) and the reaction stirred vigorously under hydrogen (ca. 1 atm). After 1 h, the catalyst was filtered off and the filtrate was concentrated to yield the title compound as a pale brown solid. MS: m/z=218 (M+1).
후처리
- filtrationthe catalyst was filtered off
- concentrationthe filtrate was concentrated
출처 및 근거
- ORD 기록
- ord-4434251d25024b12bc48e44c7413b078
- 출처 데이터셋
- uspto-grants-2007_03
- 특허 번호
- US07189722B2
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