Methyl Salicylate → Methyl 2-(2-chloroethoxy)benzoate

HRID 457778

반응식

HRID 457778 반응식
C(=O)([O-])[O-].[K+].[K+].[C:7]([O:16][CH3:17])(=[O:15])[C:8]1[C:9](=[CH:11][CH:12]=[CH:13][CH:14]=1)[OH:10].Br[CH2:19][CH2:20][Cl:21]>C(C(C)=O)C>[CH3:17][O:16][C:7](=[O:15])[C:8]1[CH:14]=[CH:13][CH:12]=[CH:11][C:9]=1[O:10][CH2:19][CH2:20][Cl:21]

참가 물질

5

반응물 3

HCID 4133Methyl SalicylateHCID 78491-Bromo-2-Chloroethane2회HCID 11430Potassium Carbonate2회

생성물 1

HCID 9837283Methyl 2-(2-chloroethoxy)benzoate

시약·촉매·용매 1

HCID 6569Methyl Ethyl Ketone용매

실험 절차

34 g (0.25 mol) of potassium carbonate were added to a solution of 25 g (0.16 mol) of methyl salicylate in 250 ml of methyl ethyl ketone. This mixture was refluxed for 1 h, then 27.3 ml (0.35 mol) of 1-bromo-2-chloro-ethane were added and the mixture was taken to reflux again. Four hours later, 34 g (0.25 mol) more of potassium carbonate and 16.3 ml (0.2 mol) more of 1-bromo-2-chloro-ethane were added. This operation was repeated until the reaction was completed. The inorganic salts were filtered off and the liquid phase was diluted with the same volume of hexane. This organic phase was washed twice with water and worked-up as usual. The yield in this step was quantitative and the product was pure enough for the next synthetic step.

후처리

  1. temperatureThis mixture was refluxed for 1 h
  2. temperatureto reflux again
  3. filtrationThe inorganic salts were filtered off
  4. additionthe liquid phase was diluted with the same volume of hexane
  5. washThis organic phase was washed twice with water
  6. customThe yield in this step

출처 및 근거

ORD 기록
ord-9aabaa3017474a3ca3687eecadcc13ca
출처 데이터셋
uspto-grants-2007_03
특허 번호
US07189741B2

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