Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
6-Fluoroindole → 6-fluoro-3-(piperidin-4-yl)-1H-indole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 6-Fluoroindole | HCID 351278 | — |
| 반응물 | Piperonylamine | HCID 2723901 | — |
| 촉매 | Adams' catalyst | HCID 345198 | — |
| 생성물 | 6-fluoro-3-(piperidin-4-yl)-1H-indole | HCID 11096077 | 51% |
반응 단계
This compound was prepared following the procedure described in example 1 (parts A and B) starting with 1 g (7.4 mmol) of 6-fluoroindol and 2.84 g (18.5 mmol) of 4-piperidone monohydrate hydrochloride. In this case, the hydrogenation step took place for 1 hour at 30 psi and the catalyst used was platinum (IV) oxide. 0.640 g (51% yield) of 6-fluoro-3-piperidin-4-yl-1H-indole were obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07189741B2 |
| 출처 데이터셋 | uspto-grants-2007_03 |
| ORD ID | ord-a88e4eccea67484fb2055c509818042c |
| 출처 메모 | uspto-grants-2007_03 |