Methyl 3-(bromomethyl)benzoate → 3-[4-(1H-indol-3-yl)-piperidin-1-ylmethyl]-benzoic acid methyl ester

HRID 457802노트

반응식

HRID 457802 반응식
[NH:1]1[CH2:6][CH2:5][CH:4]([C:7]2[C:15]3[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=3)[NH:9][CH:8]=2)[CH2:3][CH2:2]1.[CH3:16][O:17][C:18](=[O:27])[C:19]1[CH:24]=[CH:23][CH:22]=[C:21]([CH2:25]Br)[CH:20]=1>>[CH3:16][O:17][C:18](=[O:27])[C:19]1[CH:24]=[CH:23][CH:22]=[C:21]([CH2:25][N:1]2[CH2:6][CH2:5][CH:4]([C:7]3[C:15]4[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=4)[NH:9][CH:8]=3)[CH2:3][CH2:2]2)[CH:20]=1

참가 물질

3

반응물 2

HCID 517981Methyl 3-(bromomethyl)benzoateHCID 7022353-(4-Piperidinyl)-1H-indole

생성물 1

HCID 694123693-[4-(1H-indol-3-yl)-piperidin-1-ylmethyl]-benzoic acid methyl ester수율 79.2%

실험 절차

This compound was prepared following the procedure described in example 1 (part D) starting with 0.2 g (1 mmol) of 3-piperidin-4-yl-1H-indole and 0.29 g (1.3 mmol) of 3-bromomethyl-benzoic acid methyl ester. After ionic exchange purification, 0.276 g (79% of yield) of 3-[4-(1H-indol-3-yl)-piperidin-1-ylmethyl]-benzoic acid methyl ester were obtained.

후처리

  1. customThis compound was prepared
  2. customAfter ionic exchange purification

출처 및 근거

ORD 기록
ord-bc65c44d450f445f9cf7d89f28fd08e4
출처 데이터셋
uspto-grants-2007_03
특허 번호
US07189741B2

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