Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-(Chloromethyl)pyridine hydrochloride → 2-[4-(1-pyridin-3-ylmethyl-1H-indol-3-yl)-piperidin-1-ylmethyl]-nicotinic Acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-(Chloromethyl)pyridine hydrochloride | HCID 23394 | — |
| 반응물 | 2-[4-(1H-indol-3-yl)-piperidin-1-ylmethyl]-nicotinic acid ethyl ester | HCID 69411779 | — |
| 생성물 | 2-[4-(1-pyridin-3-ylmethyl-1H-indol-3-yl)-piperidin-1-ylmethyl]-nicotinic Acid | HCID 10159516 | — |
반응 단계
This compound was prepared following the procedure described in example 1 (part E) starting with 0.76 g (0.21 mmol) of 2-[4-(1H-indol-3-yl)-piperidin-1-ylmethyl]-nicotinic acid ethyl ester and 0.04 g (0.25 mmol) of 3-chloromethyl-pyridine hydrochloride. After standard purification, 0.040 g (45% of yield) of the expected acid were obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07189741B2 |
| 출처 데이터셋 | uspto-grants-2007_03 |
| ORD ID | ord-d806986ba8bd4db58d3712c538a6cf22 |
| 출처 메모 | uspto-grants-2007_03 |