Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 457829생성일: 2026년 10월 27일
4-(6-fluoro-1H-indol-3-yl)-piperidine-1-carboxylic acid ethyl ester → 4-[6-fluoro-1-(2-thiophen-3-yl-ethyl)-1H-indol-3-yl]-piperidine-1-carboxylic acid ethyl ester
https://huagongshe.com/reaction/457829
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 4-(6-fluoro-1H-indol-3-yl)-piperidine-1-carboxylic acid ethyl ester | HCID 11323738 | — |
| 반응물 | 3-Thiopheneethanol methanesulfonate | HCID 14422934 | — |
| 생성물 | 4-[6-fluoro-1-(2-thiophen-3-yl-ethyl)-1H-indol-3-yl]-piperidine-1-carboxylic acid ethyl ester | HCID 69412395 | 101.3% |
반응 단계
This compound was prepared following the procedure described in example 13 (part B) starting with 4 g (13.8 mmol) of 4-(6-fluoro-1H-indol-3-yl)-piperidine-1-carboxylic acid ethyl ester (example 24, part A) and 3.3 g (16 mmol) of 2-thiophen-3-yl-ethyl methansulfonate. The reaction mixture was stirred at 60° C. for 3 hours. After standard work-up, 5.6 g (100% of yield) of 4-[6-fluoro-1-(2-thiophen-3-yl-ethyl)-1H-indol-3-yl]-piperidine-1-carboxylic acid ethyl ester were obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US07189741B2 |
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| 출처 데이터셋 | uspto-grants-2007_03 |
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| ORD ID | ord-de6761be560c4262a651feeb08deebc2 |
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| 출처 메모 | uspto-grants-2007_03 |
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