Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-(Bromomethyl)thiophene → 4-(1-thiophen-3-ylmethyl-1H-indol-3-yl)-piperidine-1-carboxylic acid ethyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-(Bromomethyl)thiophene | HCID 520703 | — |
| 반응물 | Ethyl 4-(1H-indol-3-yl)piperidine-1-carboxylate | HCID 11380267 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 생성물 | 4-(1-thiophen-3-ylmethyl-1H-indol-3-yl)-piperidine-1-carboxylic acid ethyl ester | HCID 69413184 | 100% |
반응 단계
This compound was prepared following the procedure described in example 13 (part B) at room temperature for 15 hours, starting with 0.2 g (0.73 mmol) of 4-(1H-indol-3-yl)-piperidine-1-carboxylic acid ethyl ester and 1.64 mL (0.95 mmol) of a freshly prepared 0.6 M solution of 3-bromomethylthiophene in ethyl ether. After standard work-up, 0.27 g (100% of yield) of 4-(1-thiophen-3-ylmethyl-1H-indol-3-yl)-piperidine-1-carboxylic acid ethyl ester were obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07189741B2 |
| 출처 데이터셋 | uspto-grants-2007_03 |
| ORD ID | ord-a6d5d601be254f6abfedac8230864914 |
| 출처 메모 | uspto-grants-2007_03 |