Guanidine Hydrochloride → 4-(2-Furyl)-5-(4-pyridyl)-2-pyrimidinyl amine

HRID 457875노트

반응식

HRID 457875 반응식
CN(C)[CH:3]=[C:4]([C:12]1[CH:17]=[CH:16][N:15]=[CH:14][CH:13]=1)[C:5]([C:7]1[O:8][CH:9]=[CH:10][CH:11]=1)=O.Cl.[NH2:20][C:21]([NH2:23])=[NH:22].C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O.O>[O:8]1[CH:9]=[CH:10][CH:11]=[C:7]1[C:5]1[C:4]([C:12]2[CH:13]=[CH:14][N:15]=[CH:16][CH:17]=2)=[CH:3][N:20]=[C:21]([NH2:23])[N:22]=1

참가 물질

6

반응물 3

HCID 5742Guanidine HydrochlorideHCID 11430Potassium CarbonateHCID 670738543-(Dimethylamino)-1-(furan-2-yl)-2-(pyridin-4-yl)prop-2-en-1-one

생성물 1

HCID 97947204-(2-Furyl)-5-(4-pyridyl)-2-pyrimidinyl amine수율 80%

시약·촉매·용매 2

HCID 962Water용매HCID 6228Dimethylformamide용매

반응 조건

온도
70 °C

실험 절차

A suspension of 3-(dimethylamino)-1-(2-furyl)-2-(4-pyridyl)-2-propene-1-one (2.2 g, 9.08 mmol), guanidine hydrochloride (2.6 g, 27.2 mmol) and potassium carbonate (7.5 g, 54.3 mmol) in N,N-dimethylformamide (20 mL) was stirred at 70° C. for 12 hours. After cooling as it was, the reaction mixture was diluted with water. The resulting crystals were collected by filtration and washed with water, to give the title compound (1.73 g, 80%) as a pale yellow solid.

후처리

  1. temperatureAfter cooling as it
  2. filtrationThe resulting crystals were collected by filtration
  3. washwashed with water

출처 및 근거

ORD 기록
ord-6d8106a2920646acb514d843bfc9b85c
출처 데이터셋
uspto-grants-2007_03
특허 번호
US07189717B2

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