2,6-Difluorobenzoic acid → 2,6-difluoro-N-[4-methyl-5-(2-nitrooxy-ethyl)-thiazol-2-yl]-benzamide

반응식

[F:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]([F:11])[C:3]=1[C:4]([OH:6])=O.[CH3:12][C:13]1[N:14]=[C:15]([NH2:24])[S:16][C:17]=1[CH2:18][CH2:19][O:20][N+:21]([O-:23])=[O:22]>>[F:11][C:7]1[CH:8]=[CH:9][CH:10]=[C:2]([F:1])[C:3]=1[C:4]([NH:24][C:15]1[S:16][C:17]([CH2:18][CH2:19][O:20][N+:21]([O-:23])=[O:22])=[C:13]([CH3:12])[N:14]=1)=[O:6]

참가 물질

반응물 2

HCID 97962,6-Difluorobenzoic acid

HCID 115574994-Methyl-5-(2-nitrooxy-ethyl)-thiazol-2-ylamine

생성물 1

HCID 184408412,6-difluoro-N-[4-methyl-5-(2-nitrooxy-ethyl)-thiazol-2-yl]-benzamide수율 72%

실험 절차

Pet-161 was prepared according to the general procedure described hereinabove and the procedure described above for the preparation of Pet-154, using 2,6-difluoro-benzoic acid and 4-methyl-5-(2-nitrooxy-ethyl)-thiazol-2-ylamine (Pet-10) as the starting materials, in an overall yield of 72%.

후처리

customPet-161 was prepared
customthe procedure described above for the preparation of Pet-154

출처 및 근거

ORD 기록: ord-360125dfa2fc4ab89b04edcd2bdb9f7c
출처 데이터셋: uspto-grants-2007_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07189750B2

반응 노트

불러오는 중…