tert-Butyl isocyanate → 1-tert-Butyl-3-(2-(4-(6-methoxy-napthalen-2-yl)-5-pyridin-4-yl-1H-imidazol-2-yl)-2-methyl-propyl)-urea

HRID 457900노트

반응식

HRID 457900 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[CH:9]=[C:8]([C:13]1[N:14]=[C:15]([C:24]([CH3:28])([CH3:27])[CH2:25][NH2:26])[NH:16][C:17]=1[C:18]1[CH:23]=[CH:22][N:21]=[CH:20][CH:19]=1)[CH:7]=[CH:6]2.[C:29]([N:33]=[C:34]=[O:35])([CH3:32])([CH3:31])[CH3:30]>>[C:29]([NH:33][C:34]([NH:26][CH2:25][C:24]([C:15]1[NH:16][C:17]([C:18]2[CH:23]=[CH:22][N:21]=[CH:20][CH:19]=2)=[C:13]([C:8]2[CH:7]=[CH:6][C:5]3[C:10](=[CH:11][CH:12]=[C:3]([O:2][CH3:1])[CH:4]=3)[CH:9]=2)[N:14]=1)([CH3:28])[CH3:27])=[O:35])([CH3:32])([CH3:31])[CH3:30]

참가 물질

3

반응물 2

HCID 62412tert-Butyl isocyanateHCID 18440775HCID 18440775, 화합물

생성물 1

HCID 184407701-tert-Butyl-3-(2-(4-(6-methoxy-napthalen-2-yl)-5-pyridin-4-yl-1H-imidazol-2-yl)-2-methyl-propyl)-urea수율 39%

실험 절차

The title compound (10 mg, 39%) was prepared starting from the product of Example 2 and tert-butyl isocyanate using the method described in Example 10; MS(ES) m/e 472 [M+H]+.

출처 및 근거

ORD 기록
ord-d00c9e2846f143ff8d761925de0532b2
출처 데이터셋
uspto-grants-2007_03
특허 번호
US07189745B1

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