Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
O-((4-Methoxyphenyl)methyl)hydroxylamine → Tert-butoxycarbonyl-4-{[(4-methoxybenzyl)oxy]imino}-2-pyrrolidine-carboxylic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | O-((4-Methoxyphenyl)methyl)hydroxylamine | HCID 120426 | — |
| 반응물 | (2S)-1-(tert-butoxycarbonyl)-4-oxopyrrolidine-2-carboxylic acid | HCID 11593804 | — |
| 반응물 | tert-butoxycarbonyl-4-(methoxyimino)-2-Pyrrolidinecarboxylic acid | HCID 72828956 | — |
| 생성물 | Tert-butoxycarbonyl-4-{[(4-methoxybenzyl)oxy]imino}-2-pyrrolidine-carboxylic acid | HCID 73876899 | 85% |
반응 단계
The same method as employed in the preparation of Intermediate 7, but starting from (2S)-1-(tert-butoxycarbonyl)-4-oxo-2-pyrrolidinecarboxylic acid (Intermediate 1) and 1[(aminooxy)methyl]-4-methoxy-benzene (Intermediate 10) gave the title compound as a gum in a 85% yield.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07189754B2 |
| 출처 데이터셋 | uspto-grants-2007_03 |
| ORD ID | ord-235e92cbb3e34fcf9cf44aa06c42ac6b |
| 출처 메모 | uspto-grants-2007_03 |