Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methanol → Methyl (2S,4EZ)-1-[(2'-cyano[1,1'-biphenyl]-4-yl)carbonyl]-4-(methoxyimino)-2-pyrrolidinecarboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methanol | HCID 887 | — |
| 반응물 | 4-(2-cyanophenyl)benzoic Acid | HCID 10727789 | — |
| 반응물 | (2S,4EZ)-1(tert-butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid | HCID 58714586 | — |
| 생성물 | Methyl (2S,4EZ)-1-[(2'-cyano[1,1'-biphenyl]-4-yl)carbonyl]-4-(methoxyimino)-2-pyrrolidinecarboxylate | HCID 131726291 | — |
반응 단계
Following the general method as outlined in Example 11, starting from (2S,4EZ)-1-(tert-butoxycarbonyl)-4-(methoxyimino)-2-pyrrolidinecarboxylic acid, 2′-cyano[1,1′-biphenyl]-4-carboxylic acid, and methanol, the title compound was isolated as a mixture of two isomers in 91.6% purity by HPLC.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07189754B2 |
| 출처 데이터셋 | uspto-grants-2007_03 |
| ORD ID | ord-b371f7490fb64ff496c2c69ebcc534c5 |
| 출처 메모 | uspto-grants-2007_03 |