Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetyl chloride → 4-(4-Methylpiperazin-1-yl)phenyl acetate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetyl chloride | HCID 6367 | — |
| 반응물 | 4-(4-Methyl-1-piperazinyl)phenol | HCID 11622486 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 4-(4-Methylpiperazin-1-yl)phenyl acetate | HCID 67973796 | — |
반응 단계
A mixture of 4-(4-methylpiperazin-1-yl)phenol 1.080 mg (5.59 mmol) and TEA 1.72 ml (12.3 mmol) in DCM was cooled in an ice bath and 0.44 ml (6.15 mmol) of acetyl chloride were added dropwise. After completion, the reaction was filtered, the organic phase quickly extracted with water, dried over Na2SO4 and evaporated down to give a light pink solid. LC/MS (m/z): 235.4 [M+H]+, HPLC (254 nm) method 3 Rt 1.89 min.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08541576B2 |
| 출처 데이터셋 | uspto-grants-2013_09 |
| ORD ID | ord-ceedaa7f8b0344ddb93c9ecc488533c5 |
| 출처 메모 | uspto-grants-2013_09 |