Acetyl chloride → 4-(4-Methylpiperazin-1-yl)phenyl acetate

HRID 45807

반응식

HRID 45807 반응식
[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([C:8]2[CH:13]=[CH:12][C:11]([OH:14])=[CH:10][CH:9]=2)[CH2:4][CH2:3]1.[C:15](Cl)(=[O:17])[CH3:16]>C(Cl)Cl>[C:15]([O:14][C:11]1[CH:12]=[CH:13][C:8]([N:5]2[CH2:4][CH2:3][N:2]([CH3:1])[CH2:7][CH2:6]2)=[CH:9][CH:10]=1)(=[O:17])[CH3:16]

참가 물질

4

반응물 2

HCID 6367Acetyl chlorideHCID 116224864-(4-Methyl-1-piperazinyl)phenol

생성물 1

HCID 679737964-(4-Methylpiperazin-1-yl)phenyl acetate

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A mixture of 4-(4-methylpiperazin-1-yl)phenol 1.080 mg (5.59 mmol) and TEA 1.72 ml (12.3 mmol) in DCM was cooled in an ice bath and 0.44 ml (6.15 mmol) of acetyl chloride were added dropwise. After completion, the reaction was filtered, the organic phase quickly extracted with water, dried over Na2SO4 and evaporated down to give a light pink solid. LC/MS (m/z): 235.4 [M+H]+, HPLC (254 nm) method 3 Rt 1.89 min.

후처리

  1. temperaturewas cooled in an ice bath
  2. filtrationAfter completion, the reaction was filtered
  3. extractionthe organic phase quickly extracted with water
  4. dry with materialdried over Na2SO4
  5. customevaporated down
  6. customto give a light pink solid

출처 및 근거

ORD 기록
ord-ceedaa7f8b0344ddb93c9ecc488533c5
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08541576B2

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