HCID 178526612, 화합물 → HCID 178507541, 화합물

HRID 45813

반응식

HRID 45813 반응식
[N+:1]([C:4]1[CH:5]=[C:6]([C:10]2[C:14]([C:15]3[CH:20]=[CH:19][N:18]=[CH:17][CH:16]=3)=[CH:13][NH:12][N:11]=2)[CH:7]=[CH:8][CH:9]=1)([O-])=O>CO.[Pd]>[N:18]1[CH:17]=[CH:16][C:15]([C:14]2[C:10]([C:6]3[CH:5]=[C:4]([NH2:1])[CH:9]=[CH:8][CH:7]=3)=[N:11][NH:12][CH:13]=2)=[CH:20][CH:19]=1

참가 물질

4

반응물 1

HCID 178526612HCID 178526612, 화합물

생성물 1

HCID 178507541HCID 178507541, 화합물수율 98%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

1.27 g (4.77 mmol) of 4-[3-(3-nitro-phenyl)-1H-pyrazol-4-yl]-pyridine was suspended in methanol (200 mL). Pd/C 10% (250 mg) was added and the mixture was agitated under hydrogen pressure (50 psi) in a Parr apparatus at room temperature for 4 hours. The catalyst was then filtered on a Celite pad and washed with methanol. The filtrate was concentrated to dryness to obtain 1.1 g (98% yield) of 3-(4-pyridin-4-yl-1H-pyrazol-3-yl)-phenylamine as an off-white solid.

후처리

  1. filtrationThe catalyst was then filtered on a Celite pad
  2. washwashed with methanol
  3. concentrationThe filtrate was concentrated to dryness

출처 및 근거

ORD 기록
ord-fd89aa0474bd4d428b81fa8a470d17d1
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08541575B2

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