Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 4582생성일: 2026년 10월 25일
Ethanol → 2-(4-Acetylaminophenoxy)ethyl 2,6-dimethyl-5-(2-ethylthioethoxycarbonyl)-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate
https://huagongshe.com/reaction/4582
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Ethanol | HCID 702 | — |
| 반응물 | 2-(4-Acetylaminophenoxy)ethyl 2-(3-nitrobenzylidene)acetylacetate | HCID 57315737 | — |
| 반응물 | 2-Ethylthioethyl 3-aminocrotonate | HCID 86741408 | — |
| 생성물 | 2-(4-Acetylaminophenoxy)ethyl 2,6-dimethyl-5-(2-ethylthioethoxycarbonyl)-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate | HCID 20151264 | 60% |
반응 단계
15 g (0.04 moles) of 2-(4-acetylaminophenoxy)ethyl 2-(3-nitrobenzylidene)acetylacetate and 6.88 g (0.04 moles) of 2-ethylthioethyl 3-aminocrotonate were heated under reflux in 35 ml of ethanol for 8 hours. The solution was then cooled to -5° C. to obtain 2-(4-acetylaminophenoxy)ethyl 2,6-dimethyl-5-(2-ethylthioethoxycarbonyl)-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate as a yellow powder melting--after recrystallisation in ethanol--at 100°-104° C. The yield is 60% of the theoretical yield.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US04727066 |
|---|
| 출처 데이터셋 | uspto-grants-1988_02 |
|---|
| ORD ID | ord-0762afb0cbd843a58951b15e1705bb6e |
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| 출처 메모 | uspto-grants-1988_02 |
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