Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-(Mercaptomethyl)cyclopropaneacetic acid → Montelukast
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-(Mercaptomethyl)cyclopropaneacetic acid | HCID 9793825 | — |
| 반응물 | 2-(2-(3(S)-(3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-methanesulfonyloxypropyl)phenyl)-2-propanol | HCID 54484483 | — |
| 생성물 | Montelukast | HCID 5281040 | — |
반응 단계
In U.S. Pat. No. 5,614,632, montelukast is prepared by condensing 1-(mercaptomethyl)cyclopropaneacetic acid then condensation with 2-(2-(3(S)-(3-(2-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-methanesulfonyloxypropyl)phenyl)-2-propanol compound to afford Montelukast. It is further converted to its corresponding sodium salt via dicyclohexyl amine salt.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07189853B2 |
| 출처 데이터셋 | uspto-grants-2007_03 |
| ORD ID | ord-0716dbb845534c8e803484927cb7cd71 |
| 출처 메모 | uspto-grants-2007_03 |