참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Potassium Hydroxide | HCID 14797 | — |
| 반응물 | Ethyl-2-tert-butoxycarbonyloxyamino-4-methyl-thiazole-5-carboxylate | HCID 21911455 | — |
| 용매 | 2-(Oxolan-2-yl)ethan-1-ol | HCID 11989572 | — |
| 생성물 | 2-Tert-butoxycarbonyloxyamino-4-methyl-thiazole-5-carboxylic acid | HCID 21911430 | — |
반응 단계
A stirred solution of ethyl-2-tert-butoxycarbonyloxyamino-4-methyl-thiazole-5-carboxylate (10 g, 34.95 mmol) in tetrahydrofuran-ethanol (250 mL, 2:3) was treated with a 6N KOH solution (250 mL). The mixture was heated to 55° C. overnight. The solution was cooled to 0° C. and acidified with concd. HCl to pH 1. The solvent was evaporated in vacuo. The residue was washed with water, diethyl ether, dried in vacuo over anhydrous phosphorous pentoxide to obtain the title acid (6 g, 89%) as a white solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07189854B2 |
|---|
| 출처 데이터셋 | uspto-grants-2007_03 |
|---|
| ORD ID | ord-26345d7f07bf4078993b2a1d11025717 |
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| 출처 메모 | uspto-grants-2007_03 |
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