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C([O:3][C:4]([C:6]1[S:10][C:9]([NH:11][O:12][C:13]([O:15][C:16]([CH3:19])([CH3:18])[CH3:17])=[O:14])=[N:8][C:7]=1[CH3:20])=[O:5])C.[OH-].[K+].Cl>O1CCCC1CCO>[C:16]([O:15][C:13]([O:12][NH:11][C:9]1[S:10][C:6]([C:4]([OH:5])=[O:3])=[C:7]([CH3:20])[N:8]=1)=[O:14])([CH3:19])([CH3:17])[CH3:18]참가 물질
5
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- 온도
- 55 °C
실험 절차
A stirred solution of ethyl-2-tert-butoxycarbonyloxyamino-4-methyl-thiazole-5-carboxylate (10 g, 34.95 mmol) in tetrahydrofuran-ethanol (250 mL, 2:3) was treated with a 6N KOH solution (250 mL). The mixture was heated to 55° C. overnight. The solution was cooled to 0° C. and acidified with concd. HCl to pH 1. The solvent was evaporated in vacuo. The residue was washed with water, diethyl ether, dried in vacuo over anhydrous phosphorous pentoxide to obtain the title acid (6 g, 89%) as a white solid.
후처리
- temperatureThe solution was cooled to 0° C.
- customThe solvent was evaporated in vacuo
- washThe residue was washed with water, diethyl ether
- dry with materialdried in vacuo over anhydrous phosphorous pentoxide
- customto obtain the title acid (6 g, 89%) as a white solid
출처 및 근거
- ORD 기록
- ord-26345d7f07bf4078993b2a1d11025717
- 출처 데이터셋
- uspto-grants-2007_03
- 특허 번호
- US07189854B2
연결된 노트
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