2-Bromo-5-nitrobenzoic acid → 5-Amino-2-bromobenzoic acid

HRID 458261

반응식

HRID 458261 반응식
[Br:1][C:2]1[CH:10]=[CH:9][C:8]([N+:11]([O-])=O)=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[H][H]>CO.[Pd]>[NH2:11][C:8]1[CH:9]=[CH:10][C:2]([Br:1])=[C:3]([CH:7]=1)[C:4]([OH:6])=[O:5]

참가 물질

5

반응물 2

HCID 2430252-Bromo-5-nitrobenzoic acidHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 27696245-Amino-2-bromobenzoic acid수율 91.2%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

A mixture of 2-bromo-5-nitrobenzoic acid (1.10 g, 4.06 mmol) (Aldrich, 38, 184-5), activated Pd-C (43.62 mg, 0.41 mmol)(Aldrich, 20, 569-9) in methanol (30 ml) was hydrogenated for 4 hr under 30 psi of hydrogen pressure. After the mixture was filtered, the filtrate was concentrated to give 0.80 g (91.2% yield) of 5-amino-2-bromobenzoic acid as a pale yellow solid.

후처리

  1. filtrationAfter the mixture was filtered
  2. concentrationthe filtrate was concentrated

출처 및 근거

ORD 기록
ord-1c868e974f0a4374a47e8145ed0656d3
출처 데이터셋
uspto-grants-2007_03
특허 번호
US07189878B2

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