Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-(Trifluoromethyl)-2,3,5,6-tetrafluorobenzyl bromide → 2-Methoxy-5-(2,3,5,6-tetrafluoro-4-trifluoromethylbenzylamino)benzoic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-(Trifluoromethyl)-2,3,5,6-tetrafluorobenzyl bromide | HCID 127137 | — |
| 반응물 | 5-Amino-2-methoxybenzoic acid | HCID 13549244 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 2-Methoxy-5-(2,3,5,6-tetrafluoro-4-trifluoromethylbenzylamino)benzoic acid | HCID 10046332 | 31.5% |
반응 단계
According to the similar procedure in Synthesis Example 1, by using 5-amino-2-methoxy-benzoic acid (2.10 g, 12.7 mmole), DMF (50 ml), TEA (6 ml), and 2,3,5,6-tetrafluoro-4-trifluoromethylbenzyl bromide (2.00 ml, 14.0 mmole), 1.50 g (31.5% yield) of 2-methoxy-5-(2,3,5,6-tetrafluoro-4-trifluoromethylbenzylamino)benzoic acid was obtained as a yellow solid:
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07189878B2 |
| 출처 데이터셋 | uspto-grants-2007_03 |
| ORD ID | ord-4e81a2907878426d8e423b4fba2a6471 |
| 출처 메모 | uspto-grants-2007_03 |