Ethanol → 2-(N-nicotinoylamino)ethyl 2,6-dimethyl-5-methoxycarbonyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate

HRID 4584

반응식

HRID 4584 반응식
[N+:1]([C:4]1[CH:5]=[C:6](C=C[CH:28]=1)[CH:7]=[CH:8][C:9]([CH2:11][C:12]([O:14][CH2:15][CH2:16][NH:17][C:18](=[O:25])[C:19]1[CH:24]=[CH:23][CH:22]=[N:21][CH:20]=1)=[O:13])=O)([O-:3])=[O:2].[NH2:29]/[C:30](/[CH3:36])=[CH:31]\[C:32]([O:34][CH3:35])=[O:33].[CH2:37](O)[CH3:38]>>[CH3:37][C:38]1[NH:29][C:30]([CH3:36])=[C:31]([C:32]([O:34][CH3:35])=[O:33])[CH:9]([C:8]2[CH:7]=[CH:6][CH:5]=[C:4]([N+:1]([O-:3])=[O:2])[CH:28]=2)[C:11]=1[C:12]([O:14][CH2:15][CH2:16][NH:17][C:18](=[O:25])[C:19]1[CH:24]=[CH:23][CH:22]=[N:21][CH:20]=1)=[O:13]

참가 물질

4

반응물 3

HCID 702EthanolHCID 643918Methyl 3-aminocrotonateHCID 539056402-(N-nicotinoylamino)ethyl 2-(3-nitrobenzylidene)acetylacetate

생성물 1

HCID 201512612-(N-nicotinoylamino)ethyl 2,6-dimethyl-5-methoxycarbonyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate수율 70%

실험 절차

25 g (0.07 moles) of 2-(N-nicotinoylamino)ethyl 2-(3-nitrobenzylidene)acetylacetate and 7.51 g (0.07 moles) of methyl 3-aminocrotonate are heated uner reflux in 70 ml of ethanol for 45 minute. The solution is the cooled to room temperature to obtain 2-(N-nicotinoylamino)ethyl 2,6-dimethyl-5-methoxycarbonyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate as yellow crystals melting--after recrystallisation in ethanol--at 207°-209° C. The yield is 70% of the theoretical yield.

출처 및 근거

ORD 기록
ord-b5c35d1e26be4d9da180372b4123f748
출처 데이터셋
uspto-grants-1988_02
특허 번호
US04727066

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