Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Octoxybenzoyl hydrazine → 3,5-dibromo-N'-[4-(octyloxy)benzoyl]benzohydrazide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Octoxybenzoyl hydrazine | HCID 4281533 | — |
| 반응물 | 3,5-Dibromobenzoyl chloride | HCID 13450526 | — |
| 반응물 | 2-(2,5-Dibromophenyl)-5-[4-(octyloxy)phenyl]-1,3,4-oxadiazole | HCID 21982073 | — |
| 생성물 | 3,5-dibromo-N'-[4-(octyloxy)benzoyl]benzohydrazide | HCID 21982081 | 36% |
반응 단계
By the general method for the synthesis of 2-(2,5-dibromophenyl)-5-[4-(octyloxy)phenyl]-1,3,4-oxadiazole in Example 1, the reaction of 3,5-dibromobenzoyl chloride (20.13 g, 0.06747 mole) with 4-octyloxybenzoic acid hydrazide (17 g, 0.06747 mole) gave the intermediate 3,5-dibromo-N′-[4-(octyloxy)benzoyl]benzohydrazide (12.87 g, 36% yield). Cyclocondensation of the intermediate 3,5-dibromo-N′-[4-(octyloxy)benzoyl]-benzohydrazide (12.17 g) with POCl3 (63 mL) gave the required 2-(3,5-dibromophenyl)-5-[4-(octyloxy)phenyl]-1,3,4-oxadiazole (6.12 g, 52% yield).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07192657B2 |
| 출처 데이터셋 | uspto-grants-2007_03 |
| ORD ID | ord-def7b1a82ede453eb42287d0f43d1b25 |
| 출처 메모 | uspto-grants-2007_03 |