Nitric Acid → Spiro(5-nitroindane)-2,5'-hydantoin

반응식

[CH2:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][C:2]21[C:13](=[O:14])[NH:12][C:11](=[O:15])[NH:10]2.[N+:16]([O-])([OH:18])=[O:17]>>[N+:16]([C:6]1[CH:5]=[C:4]2[C:9](=[CH:8][CH:7]=1)[CH2:1][C:2]1([C:13](=[O:14])[NH:12][C:11](=[O:15])[NH:10]1)[CH2:3]2)([O-:18])=[O:17]

참가 물질

반응물 2

HCID 944Nitric Acid

HCID 2799991',3'-Dihydrospiro[imidazolidine-4,2'-indene]-2,5-dione2회

생성물 1

HCID 16638331Spiro(5-nitroindane)-2,5'-hydantoin

실험 절차

A solution of (±)-spiro[imidazolidine-4,2′-indane]-2,5-dione (3.0 g, 14.8 mmol, described in Intermediate 12) in conc. nitric acid (33 mL) was stirred at ambient temperature for 1 h. The reaction was then poured onto crushed ice and the resultant solid was isolated by filtration. The crude material was recrystallized from ethanol to give the title compound as a yellow solid. MS: m/z=248 (M+1).

후처리

additionThe reaction was then poured
customonto crushed ice
customthe resultant solid was isolated by filtration
customThe crude material was recrystallized from ethanol

출처 및 근거

ORD 기록: ord-a1ead9f47a9440168fbf3b7bc003358a
출처 데이터셋: uspto-grants-2007_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07192954B2

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