Nitric Acid → (+/-)-3-Methyl-5'-nitro-spiro[imidazolidine-4,2'-indane]-2,5-dione

HRID 458548노트

반응식

HRID 458548 반응식
[N+:1]([O-:4])(O)=[O:2].[CH3:5][N:6]1[C:10]2([CH2:18][C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[CH2:11]2)[C:9](=[O:19])[NH:8][C:7]1=[O:20]>O>[CH3:5][N:6]1[C:10]2([CH2:11][C:12]3[C:17](=[CH:16][CH:15]=[C:14]([N+:1]([O-:4])=[O:2])[CH:13]=3)[CH2:18]2)[C:9](=[O:19])[NH:8][C:7]1=[O:20]

참가 물질

4

반응물 2

HCID 944Nitric AcidHCID 18440308(+/-)-3-Methyl-spiro[imidazolidine-4,2'-indane]-2,5-dione

생성물 1

HCID 18440305(+/-)-3-Methyl-5'-nitro-spiro[imidazolidine-4,2'-indane]-2,5-dione

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To stirred fuming nitric acid (100 ml) was slowly added (±)-3-methyl-spiro[imidazolidine-4,2′-indane]-2,5-dione (4.5 g, 20.9 mmol) in portions over 30 min. The reaction mixture was diluted with H2O (200 mL) and the precipitate was collected by filtration, washed with H2O and dried in vacuo to give the title compound. MS: m/z=262 (M+1).

후처리

  1. customover 30 min
  2. filtrationthe precipitate was collected by filtration
  3. washwashed with H2O
  4. customdried in vacuo

출처 및 근거

ORD 기록
ord-90c90ed895ee4e88836a73ee045f5fa1
출처 데이터셋
uspto-grants-2007_03
특허 번호
US07192954B2

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