Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethanol → 2-(4-Acetylaminobenzoyloxy)ethyl 2,6-dimethyl-5-methoxycarbonyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethanol | HCID 702 | — |
| 반응물 | Methyl 3-aminocrotonate | HCID 643918 | — |
| 반응물 | 2-(4-Acetylaminobenzoyloxy)ethyl 2-(3-nitrobenzylidene)acetylacetate | HCID 57265676 | — |
| 생성물 | 2-(4-Acetylaminobenzoyloxy)ethyl 2,6-dimethyl-5-methoxycarbonyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate | HCID 3648746 | 94% |
반응 단계
20 g (0.05 moles) of 2-(4-acetylaminobenzoyloxy)ethyl 2-(3-nitrobenzylidene)acetylacetate and 5.23 g (0.05 moles) of methyl 3-aminocrotonate are heated under reflux in 45 ml of ethanol for 8 hours. The solution is then cooled to room temperature to obtain 2-(4-acetylaminobenzoyloxy)ethyl 2,6-dimethyl-5-methoxycarbonyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate as a yellow powder melting at 190°-193° C. The yield is 94% of the theoretical yield.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04727066 |
| 출처 데이터셋 | uspto-grants-1988_02 |
| ORD ID | ord-7474294ae7e34856979084eb68096e62 |
| 출처 메모 | uspto-grants-1988_02 |