tert-Butyl 4-(2-Ethoxy-2-oxoethylidene)piperidine-1-carboxylate → Ethyl 1-((1,1-dimethylethoxy)carbonyl)-4-piperidineacetate

HRID 458753노트

반응식

HRID 458753 반응식
[CH2:1]([O:3][C:4](=[O:19])[CH:5]=[C:6]1[CH2:11][CH2:10][N:9]([C:12]([O:14][C:15]([CH3:18])([CH3:17])[CH3:16])=[O:13])[CH2:8][CH2:7]1)[CH3:2].[H][H]>CO.[Pd]>[CH2:1]([O:3][C:4](=[O:19])[CH2:5][CH:6]1[CH2:11][CH2:10][N:9]([C:12]([O:14][C:15]([CH3:18])([CH3:17])[CH3:16])=[O:13])[CH2:8][CH2:7]1)[CH3:2]

참가 물질

5

반응물 2

HCID 10333298tert-Butyl 4-(2-Ethoxy-2-oxoethylidene)piperidine-1-carboxylateHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 9993342Ethyl 1-((1,1-dimethylethoxy)carbonyl)-4-piperidineacetate수율 93.4%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

To a solution of 355 mg of t-butyl 4-(2-ethoxy-2-oxoethylidene)tetrahydropyridine-1(2H)-carboxylate in 10 ml of methanol, 50 mg of 10% palladium-on-carbon catalyst was added and stirred for 13 hours in 3 atmospheres' hydrogen pressure. Filtering the catalyst off, the solvent was distilled off under reduced pressure to provide 334 mg of the title compound.

후처리

  1. filtrationFiltering the catalyst off, the solvent
  2. distillationwas distilled off under reduced pressure

출처 및 근거

ORD 기록
ord-86514213e8594a5aaa21e599e5e07c95
출처 데이터셋
uspto-grants-2007_03
특허 번호
US07192969B2

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