Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dichloromethane → 3-(4-Benzyloxy-3-methoxy-phenyl)-propionic acid benzyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dichloromethane | HCID 6344 | — |
| 반응물 | Benzyl Bromide | HCID 7498 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | Dihydroferulic Acid | HCID 14340 | — |
| 용매 | Acetone | HCID 180 | — |
| 생성물 | 3-(4-Benzyloxy-3-methoxy-phenyl)-propionic acid benzyl ester | HCID 69353460 | 180.5% |
반응 단계
A mixture of 3-(4-hydroxy-3-methoxy-phenyl)-propionic acid (5.1 g, 25.99 mmol), anhydrous K2CO3 (25 g, 180.88 mmol) and benzyl bromide (7.5 ml, 63.14 mmol) in anhydrous acetone (100 ml) was stirred at reflux for 7.5 h under nitrogen. After cooling, the reaction mixture was filtered and concentrated in vacuo. Flash chromatography (CH2Cl2) gave the title compound (8.83 g, 23.45 mmol, 90%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07192950B2 |
| 출처 데이터셋 | uspto-grants-2007_03 |
| ORD ID | ord-7466c945d5f9454a84cc85d0aed68e9a |
| 출처 메모 | uspto-grants-2007_03 |