(R)-3-Pyrrolidinol → (3R)-1-(3-thien-2-ylpropyl)pyrrolidin-3-ol

반응식

[NH:1]1[CH2:5][CH2:4][C@@H:3]([OH:6])[CH2:2]1.Br[CH2:8][CH2:9][CH2:10][C:11]1[S:12][CH:13]=[CH:14][CH:15]=1>>[S:12]1[CH:13]=[CH:14][CH:15]=[C:11]1[CH2:10][CH2:9][CH2:8][N:1]1[CH2:5][CH2:4][C@@H:3]([OH:6])[CH2:2]1

참가 물질

반응물 2

HCID 2759337(R)-3-Pyrrolidinol

HCID 115575122-(3-Bromopropyl)thiophene

생성물 1

HCID 11820472(3R)-1-(3-thien-2-ylpropyl)pyrrolidin-3-ol수율 85%

실험 절차

Prepared as in Intermediate I-15 from (3R)pyrrolidin-3-ol (commercially available) and 2-(3-bromopropyl)thiophene. The yield was 1.02 g (85%) of the title compound.

출처 및 근거

ORD 기록: ord-437a5c409c314098b06d3a146dcb77e0
출처 데이터셋: uspto-grants-2007_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07192978B2

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