p-(4-(Trifluoromethyl)phenoxy)phenol → (2S)-2-Methoxy-3-(4-{3-[4-(4-trifluoromethyl-phenoxy)-phenoxy]-prop-1-ynyl}-phenyl)-propionic acid

HRID 459078노트

반응식

HRID 459078 반응식
C([O:3][C:4](=[O:19])[C@@H:5]([O:17][CH3:18])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([C:13]#[C:14][CH2:15]Cl)=[CH:9][CH:8]=1)C.[F:20][C:21]([F:37])([F:36])[C:22]1[CH:35]=[CH:34][C:25]([O:26][C:27]2[CH:32]=[CH:31][C:30]([OH:33])=[CH:29][CH:28]=2)=[CH:24][CH:23]=1>>[CH3:18][O:17][C@@H:5]([CH2:6][C:7]1[CH:8]=[CH:9][C:10]([C:13]#[C:14][CH2:15][O:33][C:30]2[CH:31]=[CH:32][C:27]([O:26][C:25]3[CH:34]=[CH:35][C:22]([C:21]([F:20])([F:36])[F:37])=[CH:23][CH:24]=3)=[CH:28][CH:29]=2)=[CH:11][CH:12]=1)[C:4]([OH:3])=[O:19]

참가 물질

3

반응물 2

HCID 170230p-(4-(Trifluoromethyl)phenoxy)phenolHCID 58822943(2S)-3-[4-(3-Chloro-prop-1-ynyl)-phenyl]-2-methoxy-propionic acid ethyl ester

생성물 1

HCID 10278182(2S)-2-Methoxy-3-(4-{3-[4-(4-trifluoromethyl-phenoxy)-phenoxy]-prop-1-ynyl}-phenyl)-propionic acid

실험 절차

The title compound was prepared from (2S)-3-[4-(3-Chloro-prop-1-ynyl)-phenyl]-2-methoxy-propionic acid ethyl ester from Example 5 Step A and 4-(4-trifluoromethylPhenoxy)-phenol in a manner analogous to that described for Example 5, Step B. MS(ES) for C26H21F3O5 [M−H]−: 469.2

출처 및 근거

ORD 기록
ord-4bdd20f7f8734d7596fd6885e45aa051
출처 데이터셋
uspto-grants-2007_03
특허 번호
US07192982B2

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