4-Benzylphenol → (2S)-3-{4-[3-(4-Benzyl-phenoxy)-prop-1-ynyl]-phenyl}-2-methoxy-propionic acid

HRID 459087

반응식

C([O:3][C:4](=[O:19])[C@@H:5]([O:17][CH3:18])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([C:13]#[C:14][CH2:15]Cl)=[CH:9][CH:8]=1)C.[CH:20]1[CH:21]=[CH:22][C:23]([CH2:26][C:27]2[CH:28]=[CH:29][C:30]([OH:33])=[CH:31][CH:32]=2)=[CH:24][CH:25]=1>>[CH2:26]([C:27]1[CH:28]=[CH:29][C:30]([O:33][CH2:15][C:14]#[C:13][C:10]2[CH:9]=[CH:8][C:7]([CH2:6][C@H:5]([O:17][CH3:18])[C:4]([OH:3])=[O:19])=[CH:12][CH:11]=2)=[CH:31][CH:32]=1)[C:23]1[CH:22]=[CH:21][CH:20]=[CH:25][CH:24]=1

참가 물질

반응물 2

HCID 75634-Benzylphenol

HCID 58822943(2S)-3-[4-(3-Chloro-prop-1-ynyl)-phenyl]-2-methoxy-propionic acid ethyl ester

생성물 1

HCID 58822715(2S)-3-{4-[3-(4-Benzyl-phenoxy)-prop-1-ynyl]-phenyl}-2-methoxy-propionic acid

실험 절차

The title compound was prepared from (2S)-3-[4-(3-Chloro-prop-1-ynyl)-phenyl]-2-methoxy-propionic acid ethyl ester from Example 5, Step A and 4-hydroxydiphenylmethane in a manner analogous to that described for Example 5, Step B. MS(ES) for C26H24O4[M−H]−: 399.

출처 및 근거

ORD 기록: ord-c258d48a801b4a52a3ab4e32ff6fc4f8
출처 데이터셋: uspto-grants-2007_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07192982B2

연결된 노트

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