Acrylonitrile → (2-Cyanoethyl)-alpha-naphthoxymalonic acid diethyl ester

HRID 4591

반응식

HRID 4591 반응식
[C:1]([CH2:3][CH2:4]C(OC1C2C(=CC=CC=2)C=CC=1)C(O)=O)#[N:2].[OH-].[K+].[CH2:22]([O:24][C:25](=[O:43])[CH:26]([O:32][C:33]1[C:42]2[C:37](=[CH:38][CH:39]=[CH:40][CH:41]=2)[CH:36]=[CH:35][CH:34]=1)[C:27]([O:29][CH2:30][CH3:31])=[O:28])[CH3:23].C(#N)C=C>C(OCC)(=O)C>[CH2:30]([O:29][C:27](=[O:28])[C:26]([CH2:4][CH2:3][C:1]#[N:2])([O:32][C:33]1[C:42]2[C:37](=[CH:38][CH:39]=[CH:40][CH:41]=2)[CH:36]=[CH:35][CH:34]=1)[C:25]([O:24][CH2:22][CH3:23])=[O:43])[CH3:31]

참가 물질

6

반응물 4

HCID 7855AcrylonitrileHCID 14797Potassium HydroxideHCID 230496484-Cyano-2(R,S)-alpha-naphthoxybutyric acidHCID 54105534alpha-Naphthoxymalonic acid diethyl ester

생성물 1

HCID 54279623(2-Cyanoethyl)-alpha-naphthoxymalonic acid diethyl ester

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

4-Cyano-2(R,S)-α-naphthoxybutyric acid: 0.11 ml of a 50% aqueous KOH solution is added at 0°, while stirring, to a mixture of 5.0 g of α-naphthoxymalonic acid diethyl ester and 1.09 ml of acrylonitrile. The reaction mixture is stirred for 5 days at room temperature and then dissolved in ethyl acetate. The ethyl acetate solution is washed with 2N sodium bicarbonate solution, 2N hydrochloric acid and brine, dried over sodium sulphate and concentrated by evaporation, leaving (2-cyanoethyl)-α-naphthoxymalonic acid diethyl ester.

후처리

  1. washThe ethyl acetate solution is washed with 2N sodium bicarbonate solution, 2N hydrochloric acid and brine
  2. dry with materialdried over sodium sulphate
  3. concentrationconcentrated by evaporation

출처 및 근거

ORD 기록
ord-0c2d879632c7416297f9a04382172ffc
출처 데이터셋
uspto-grants-1988_02
특허 번호
US04727060

연결된 노트

불러오는 중…