6-Hydroxyflavone → (2S)-2-Methoxy-3-{4-[3-(4-oxo-2-phenyl-chroman-6-yloxy)-propoxy]-phenyl}-propionic acid

HRID 459136노트

반응식

HRID 459136 반응식
[OH:1][CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:11]=[CH:10][C:9]([CH2:12][C@H:13]([O:17][CH3:18])[C:14]([OH:16])=[O:15])=[CH:8][CH:7]=1.O[C:20]1[CH:21]=[C:22]2[C:27](=[CH:28][CH:29]=1)[O:26][C:25]([C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1)=[CH:24][C:23]2=[O:36]>>[CH3:18][O:17][C@@H:13]([CH2:12][C:9]1[CH:10]=[CH:11][C:6]([O:5][CH2:4][CH2:3][CH2:2][O:1][C:20]2[CH:21]=[C:22]3[C:27](=[CH:28][CH:29]=2)[O:26][CH:25]([C:30]2[CH:31]=[CH:32][CH:33]=[CH:34][CH:35]=2)[CH2:24][C:23]3=[O:36])=[CH:7][CH:8]=1)[C:14]([OH:16])=[O:15]

참가 물질

3

반응물 2

HCID 722796-HydroxyflavoneHCID 69424952(2S)-3-[4-(3-Hydroxy-propoxy)-phenyl]-2-methoxy-propionic acid

생성물 1

HCID 58822982(2S)-2-Methoxy-3-{4-[3-(4-oxo-2-phenyl-chroman-6-yloxy)-propoxy]-phenyl}-propionic acid

실험 절차

The title compound was prepared from (2S)-3-[4-(3-Hydroxy-propoxy)-phenyl]-2-methoxy-propionic acid linked to Wang's Resin (Example 94, Step D) via Mitsunobu coupling with 6-hydroxyflavone and cleavage from the resin (Standard Procedure G) gave an oily solid.

후처리

  1. customgave an oily solid

출처 및 근거

ORD 기록
ord-7f99744399194c24839dd147dceb4621
출처 데이터셋
uspto-grants-2007_03
특허 번호
US07192982B2

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