Guaiacol → (2S)-2-methoxy-3-{4-[3-(2-methoxy-phenoxy)-propoxy]-phenyl}-propionic acid

HRID 459319

반응식

HRID 459319 반응식
C([O:3][C:4](=[O:20])[C@@H:5]([O:18][CH3:19])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH2:14][CH2:15][CH2:16]Br)=[CH:9][CH:8]=1)C.[CH3:21][O:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][C:24]=1[OH:29].CO[C@@H](CC1C=CC(OCCCOC2C=CC=CC=2)=CC=1)C(O)=O>>[CH3:19][O:18][C@@H:5]([CH2:6][C:7]1[CH:8]=[CH:9][C:10]([O:13][CH2:14][CH2:15][CH2:16][O:29][C:24]2[CH:25]=[CH:26][CH:27]=[CH:28][C:23]=2[O:22][CH3:21])=[CH:11][CH:12]=1)[C:4]([OH:3])=[O:20]

참가 물질

4

반응물 3

HCID 460GuaiacolHCID 58822859(2S)-3-[4-(3-Bromopropoxy)-phenyl]-2-methoxy-propionic acid ethyl esterHCID 58822897(2S)-2-methoxy-3-[4-(3-phenoxy propoxy)-phenyl]-propionic acid

생성물 1

HCID 58822831(2S)-2-methoxy-3-{4-[3-(2-methoxy-phenoxy)-propoxy]-phenyl}-propionic acid

실험 절차

The title compound was prepared from (2S)-3-[4-(3-bromo-propoxy)-phenyl]-2-methoxy-propionic acid ethyl ester (Example 284, Step 2) and 2-methoxy-phenol via the same procedure used for the preparation of (2S)-2-methoxy-3-[4-(3-phenoxy-propoxy)-phenyl]-propionic acid (Example 285, Step 1), to produce a colorless oil. MS (ES) for C20H24O6 [M+NH4]+: 378.4.

후처리

  1. customto produce a colorless oil

출처 및 근거

ORD 기록
ord-ec3d85acaf404c2e88a8c3716d517123
출처 데이터셋
uspto-grants-2007_03
특허 번호
US07192982B2

연결된 노트

불러오는 중…