(1,1'-Biphenyl)-2-ol → (2S)-3-{4-[2-(biphenyl-2-yloxy)-ethoxy]-phenyl}-2-methoxy-propionic acid

HRID 459333

반응식

HRID 459333 반응식
C([O:3][C:4](=[O:19])[C@@H:5]([O:17][CH3:18])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH2:14][CH2:15]Br)=[CH:9][CH:8]=1)C.[C:20]1([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)[C:21]([OH:26])=[CH:22][CH:23]=[CH:24][CH:25]=1.CO[C@@H](CC1C=CC(OCCCOC2C=CC=CC=2)=CC=1)C(O)=O>>[C:20]1([C:27]2[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=2)[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=1[O:26][CH2:15][CH2:14][O:13][C:10]1[CH:9]=[CH:8][C:7]([CH2:6][C@H:5]([O:17][CH3:18])[C:4]([OH:3])=[O:19])=[CH:12][CH:11]=1

참가 물질

4

반응물 3

HCID 7017(1,1'-Biphenyl)-2-olHCID 58822865(2S)-3-[4-(2-bromo-ethoxy)-phenyl]2-methoxy-propionic acid ethyl esterHCID 58822897(2S)-2-methoxy-3-[4-(3-phenoxy propoxy)-phenyl]-propionic acid

생성물 1

HCID 58822810(2S)-3-{4-[2-(biphenyl-2-yloxy)-ethoxy]-phenyl}-2-methoxy-propionic acid

실험 절차

The title compound was prepared from (2S)-3-[4-(2-bromo-ethoxy)-phenyl]-2-methoxy-propionic acid ethyl ester (Example 283, Step 2) and biphenyl-2-ol via the same procedure used for the preparation of (2S)-2-methoxy-3-[4-(3-phenoxy-propoxy)-phenyl]-propionic acid (Example 285, Step 1), to produce a colorless oil. MS (ES) for C24H24O5 [M+Na]+: 415.4.

후처리

  1. customto produce a colorless oil

출처 및 근거

ORD 기록
ord-ab48810469af4ebcb430437bfe3081f8
출처 데이터셋
uspto-grants-2007_03
특허 번호
US07192982B2

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