Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
p-Xylyl bromide → (4-methylbenzyl)-1H-benzo[d]imidazol-5-amine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | p-Xylyl bromide | HCID 7721 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 5-Aminobenzimidazole | HCID 13623 | — |
| 생성물 | (4-methylbenzyl)-1H-benzo[d]imidazol-5-amine | HCID 62507494 | — |
반응 단계
The compound was synthesized starting from benzimidazol-5-amine (133 mg; 1 mmol; 1 eq.), 4-methylbenzylbromide (407 mg; 2.2 mmol; 2.2 eq.) and K2CO3 (304 mg; 2.2 mmol; 2.2 eq.) according to method 5; Yield: 0.109 g (32.0%); MS m/z: 342.1 [M+H]+; 1H-NMR (500 MHz, DMSO d6): δ 2.23 (s, 6H); 4.57 (s, 4H); 6.66 (br s, 1H); 6.71 (dd, 1H, 4J=2.1 Hz, 3J=8.9 Hz); 7.09 (d, 4H, 3J=7.9 Hz); 7.14 (d, 4H, 3J=7.9 Hz); 7.30 (d, 1H, 3J=8.5 Hz); 7.88 (s, 1H); 11.88 (br s, 1H); HPLC (METHOD [A]): rt 17.36 min (98.1%)
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08541596B2 |
| 출처 데이터셋 | uspto-grants-2013_09 |
| ORD ID | ord-d94a5eae9a8e4e068f5b1a491d04ce35 |
| 출처 메모 | uspto-grants-2013_09 |