Methyl 3-[4-(benzyloxy)phenyl]propanoate → 3-(4-Benzyloxy-phenyl)-2-ethoxy-propionic acid methyl ester

HRID 459395노트

반응식

HRID 459395 반응식
[CH2:1]([O:3][C:4](=[O:24])[C:5]([O:21][CH2:22][CH3:23])=[CH:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH2:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[CH:9][CH:8]=1)C.COC(=O)C(OC)CC1C=CC=C(OCC2C=CC=CC=2)C=1.COC(=O)CCC1C=CC(OCC2C=CC=CC=2)=CC=1>>[CH3:1][O:3][C:4](=[O:24])[CH:5]([O:21][CH2:22][CH3:23])[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][CH2:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[CH:9][CH:8]=1

참가 물질

4

반응물 3

HCID 525519Methyl 3-[4-(benzyloxy)phenyl]propanoateHCID 54423854Ethyl 3-[4-(benzyloxy)phenyl]-2-ethoxyprop-2-enoateHCID 588226203-(3-Benzyloxy-phenyl)-2-methoxy-propionic acid methyl ester

생성물 1

HCID 219309623-(4-Benzyloxy-phenyl)-2-ethoxy-propionic acid methyl ester수율 47.1%

실험 절차

The title compound was prepared from 3-(4-benzyloxy-phenyl)-2-ethoxy-acrylic acid ethyl ester (Example 375, Step 2) (3.3 gr, 10.12 mmol) via the same procedure used for the preparation of 3-(3-benzyloxy-phenyl)-2-methoxy-propionic acid methyl ester (Example 291, Step 3) to produce an oil that was purified by chromatography (silica gel, hexanes/ethyl acetate 6:1) to produce two compounds: 3-(4-benzyloxy-phenyl)-propionic acid methyl ester (1.5 gr, Rf aprox. 0.65) and the desired compound (1.5 gr, Rf aprox. 0.2).

후처리

  1. customto produce an oil that
  2. customwas purified by chromatography (silica gel, hexanes/ethyl acetate 6:1)
  3. customto produce two compounds

출처 및 근거

ORD 기록
ord-cbb72b231ebd4783aca63fbfbd482710
출처 데이터셋
uspto-grants-2007_03
특허 번호
US07192982B2

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