Potassium Carbonate → HCID 178490300, 화합물

HRID 45943

반응식

HRID 45943 반응식
[N:1]1[C:5]2[CH:6]=[CH:7][C:8]([NH2:10])=[CH:9][C:4]=2[NH:3][CH:2]=1.[CH3:11][O:12][C:13]1[CH:14]=[C:15]([CH:18]=[CH:19][CH:20]=1)[CH2:16]Br.[C:21]([O-:24])([O-])=O.[K+].[K+]>>[CH3:11][O:12][C:13]1[CH:14]=[C:15]([CH:18]=[CH:19][CH:20]=1)[CH2:16][N:10]([CH2:16][C:15]1[CH:18]=[CH:19][CH:20]=[C:13]([O:24][CH3:21])[CH:14]=1)[C:8]1[CH:7]=[CH:6][C:5]2[NH:1][CH:2]=[N:3][C:4]=2[CH:9]=1

참가 물질

4

반응물 3

HCID 11430Potassium CarbonateHCID 136235-AminobenzimidazoleHCID 40672073-Methoxybenzyl bromide

생성물 1

HCID 178490300HCID 178490300, 화합물

실험 절차

The compound was synthesized starting from benzimidazol-5-amine (133 mg; 1 mmol; 1 eq.), 3-methoxybenzylbromide (442 mg; 0.308 ml; 2.2 mmol; 2.2 eq.) and K2CO3 (304 mg; 2.2 mmol; 2.2 eq.) according to method 5; Yield: 0.143 g (38.3%); MS m/z: 374.1 [M+H]+; 1H-NMR (500 MHz, DMSO d6): δ 3.68 (s, 6H); 4.64 (s, 4H); 6.69 (br s, 1H); 6.72 (dd, 1H, 4J=2.1 Hz, 3J=8.9 Hz); 6.78 (dd, 2H, 4J=2.4 Hz, 3J=7.9 Hz); 6.83-6.87 (m, 4H); 7.22 (t, 2H, 3J=7.9 Hz); 7.33 (d, 1H, 3J=8.9 Hz); 7.90 (s, 1H); 11.92 (br s, 1H); HPLC (METHOD [A]): rt 15.00 min (92.7%)

후처리

  1. customThe compound was synthesized
  2. customrt 15.00 min (92.7%)

출처 및 근거

ORD 기록
ord-e79f6f1e388640eaa61467acfe621c48
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08541596B2

연결된 노트

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