Carbon Dioxide → Lithium 5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylate

HRID 459443노트

반응식

HRID 459443 반응식
[CH3:1][N:2]1[CH2:7][CH2:6][C:5]2[N:8]=[CH:9][S:10][C:4]=2[CH2:3]1.[C:11](=[O:13])=[O:12].C([Li:18])CCC>O1CCCC1>[CH3:1][N:2]1[CH2:7][CH2:6][C:5]2[N:8]=[C:9]([C:11]([O-:13])=[O:12])[S:10][C:4]=2[CH2:3]1.[Li+:18]

참가 물질

5

반응물 3

HCID 280Carbon DioxideHCID 111864405-Methyl-4,5,6,7-tetrahydrothiazolo(5,4-c)pyridineHCID 178418339Butyllithium

생성물 1

HCID 23704331Lithium 5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylate

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine (6.43 g) was dissolved in absolute tetrahydrofuran (200 ml), to the solution n-butyllithium (1.47N hexane solution, 34.0 ml) was added dropwise at −78° C., and the resultant mixture was stirred for 40 minutes. After carbon dioxide gas was blown into the reaction mixture at −78° C. for 1 hour, the reaction mixture was warmed to room temperature and then concentrated under reduced pressure to obtain the title compound (9.42 g) as pale brown foamy solids.

후처리

  1. additionwas added dropwise at −78° C.
  2. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-3a9daf06d1de4b20bc9440aa7fab1960
출처 데이터셋
uspto-grants-2007_03
특허 번호
US07192968B2

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